Dying Changes Everything Eight weeks after the death of his girlfriend Amber, Wilson is still mourning her death and his relationship with his best friend House is shattered. Needing to make a change in his life and give himself time to recover emotionally, Wilson resigns from Princeton-Plainsboro. He is forced to decide if House is a destructive force in his life, while House has to determine if he's responsible for the death of his best friend's girlfriend. The team must push forward as they encounter a case involving an assistant to a high-profile executive, who is a textbook "Type A" personality. The team suspects that the patient's symptoms stem from her obsession to constantly please her demanding boss. However, her shocking medical condition forces the team to rethink their initial diagnoses and see the case through House's eyes. Meanwhile, Cuddy attempts to salvage the irreparable rift between House and Wilson, and Thirteen struggles to treat the patient objectively without bringing the reality of her own medical condition to the case.
Not Cancer When several people die suddenly and without warning five years after receiving transplants from a single organ donor, House and the team rush to save the only two surviving recipients. With one already dying and other healthy but sure to fall ill at any moment, the team must find out what was wrong with the original organ donor. As the team sorts through the records on the deceased donor recipients to find the common thread, they must deal with a new intrusion. House has hired Lucas, a private investigator, to dig up information about the deceased despite the team's skepticism. Meanwhile, House auditions new best friends to replace Wilson, and soon uses Lucas for his own personal means to spy on Wilson and the other team members.
Adverse Events House and the team take on the case of a struggling artist who has been painting bizarre portraits. His undiagnosed illness is distorting his perception, threatening to undermine his career, his relationships and everything else in his life. The team soon finds out that he hasn't sold anything lately and is on three separate drug trials to pay the bills. House must unlock the puzzle of which drugs are causing which symptoms before it's too late. Meanwhile, House continues to have private investigator Lucas Douglas dig up dirt on everyone on his team, including Taub who is having trouble in his marriage.
Birthmarks When House receives word that his father has passed away, he brushes off the news and dismisses the idea of going to the funeral. However, he is soon coerced into going despite his strongest protests. Back at Princeton-Plainsboro, the team encounters the case of a young woman adopted by American parents who collapsed while in China looking for her birth parents. With House en route to his father's funeral, he must work with the team to diagnose the woman via cell phone while on the road. The team runs through possible diagnoses and various genetic disorders, but when House's phone dies, the team must decipher what House was trying to tell them before the girl's condition deteriorates. Meanwhile, the back story of how House and Wilson met for the first time is revealed.
Lucky Thirteen When a woman with whom Thirteen had a one-night stand falls ill and has a seizure at Thirteen's apartment after a night of partying, Thirteen accompanies the woman to Princeton-Plainsboro where House and the team take on her case. House jumps on the opportunity to delve into Thirteen's personal life, and he and Foreman search Thirteen's apartment to find any possible causes of the woman's illness. Thirteen suspects the woman's drug use has caused her condition, but she soon finds the patient has a long medical history and has seen several doctors over the past few years. She soon finds out the patient slept with her only to get to Dr. House, and that she had been trying to get House to take her as a patient for over a year. Foreman sees evidence of Thirteen's hard-partying lifestyle and confronts her about her self-destruction, warning her that her attitude is sending her life and her job into a downward spiral. Meanwhile, House keeps his private investigator, Lucas, hot on Wilson's trail.
Joy The team takes on the case of a dreary middle-aged man who has been experiencing unexplained recurring blackouts and time lapses. With possible diagnoses ranging from a stroke to a concussion to toxins from the consumer products he has been testing for work, they soon find that the man, who is raising his 12-year-old daughter on his own, has been experiencing intense sleepwalking spells. As the team tries to find out what he could be doing during his sleep to make himself sick, his condition continues to deteriorate and his daughter also falls gravely ill. Meanwhile, House finds out Cuddy is going to adopt a baby that is due in two weeks. But when Cuddy meets the birth mother in person and notices a strange rash on her arm, Cuddy brings the mother to Princeton-Plainsboro where her condition worsens. Cuddy must take on the case as both a doctor and a potential mother, and she and the team are faced with a heart-wrenching decision that could risk either the birth mother's or the baby's life.
The Itch When an agoraphobic man falls mysteriously ill and adamantly refuses to leave his home to get treatment at the hospital, House and the team go to him to figure out what might be wrong. Cameron takes charge as she has treated the patient before, and she and the team figure out ways to bring the hospital to the patient's home, much to Cuddy's disapproval. But as the patient's condition worsens and their options for treating him inside his home become increasingly limited, House and the team scheme to get the man into the hospital for surgery without causing any further physical trauma or emotional anxiety. Meanwhile, Cameron and Chase attempt to work through some kinks in their relationship, and House deals with an annoying itch he cannot seem to scratch as Wilson comes up with his own analogies about House's prickly situation.
Emancipation The team tackles the case of a 16-year-old factory manager and emancipated minor who falls ill at work, while Foreman takes on his own pediatric case. But when the child's unexplained illness brings him to the brink of death, Foreman is left questioning his ability to work without House's oversight.
Last Resort A man willing to kill or die for a diagnosis takes House, Thirteen and several patients from the hospital waiting room hostage in Cuddy's office. With one person shot, other patients needing medical attention, Thirteen being used as a guinea pig and the SWAT team closing in, House is determined to end the standoff the only way he knows how: by coming up with the right diagnosis.
Let Them Eat Cake House and the team take on the case of a high-profile fitness trainer who collapses while shooting an infomercial. As the team tests her for possible conditions such as exercise-induced asthma, steroid abuse or even a possible vitamin deficiency due to her strict diet, the patient's condition continues to worsen. Though she touts herself as an all-natural fitness guru, the team soon discovers she has a slimming secret that may be contributing to her deteriorating condition. Meanwhile, Thirteen begins her participation in a clinical drug trial for Huntington's disease led by Foreman, Kutner sets up and runs an online medical advice clinic under House's name and Cuddy moves into House's office while hers is being repaired, much to the dismay of her new officemate.
Joy To The World House and the team encounter a teenager who collapsed during her high school Christmas program. They soon find the troubled teen dealt with more than her share of bullying at school, and as her condition continues to deteriorate, the team must delve deeper to get to the bottom of her mysterious illness. Foreman continues to work with Thirteen on the Huntington's disease drug trial, and their relationship progresses when he learns a valuable lesson from her. House gives a clinic patient an unbelievable holiday gift and keeps the team guessing about who may have sent him a particularly thoughtful Christmas present. Meanwhile, Cuddy receives an unexpected gift of her own.
Painless House and the team try to diagnose a man living with severe, chronic pain; Thirteen and Foreman explore their complicated relationship; Cuddy discovers that caring for her baby leaves her with little time to run the hospital.
